How does tissue fluid return to the blood




















If it is not returned continuously, tissues will swell and blood volume will decline. Moreover, blood capillary walls are fenestrated, and white blood cells walk out through those endothelial pores to enter tissue fluid by a process called diapedesis.

So along with tissue fluid white blood cells must also return to circulation in the form of lymph. Lymph is drained very slowly but continuously in venous blood by two large lymphatic ducts. Other than plasma proteins and white cells, lymph contains triglycerides fat.

Does the lymphatic system take up excess tissue fluid at the site of capillaries? Does it contain the same proteins as blood? Mandira P. Nov 6, Explanation: In closed circulatory system blood does not come in direct contact with tissue cells.

People who smoke often have cold hands and feet. There are blood capillaries and special lymph capillaries, called lacteals , in the center of each villus. The blood capillaries absorb most nutrients, but the fats and fat-soluble vitamins are absorbed by the lacteals. The lymph in the lacteals has a milky appearance due to its high fat content and is called chyle. The third and probably most well known function of the lymphatic system is defense against invading microorganisms and disease.

Lymph nodes and other lymphatic organs filter the lymph to remove microorganisms and other foreign particles. Osmotic pressure is determined by osmotic concentration gradients, that is, the difference in the solute-to-water concentrations in the blood and tissue fluid. A region higher in solute concentration and lower in water concentration draws water across a semipermeable membrane from a region higher in water concentration and lower in solute concentration.

As we discuss osmotic pressure in blood and tissue fluid, it is important to recognize that the formed elements of blood do not contribute to osmotic concentration gradients. Rather, it is the plasma proteins that play the key role. Solutes also move across the capillary wall according to their concentration gradient, but overall, the concentrations should be similar and not have a significant impact on osmosis.

Because of their large size and chemical structure, plasma proteins are not truly solutes, that is, they do not dissolve but are dispersed or suspended in their fluid medium, forming a colloid rather than a solution. The pressure created by the concentration of colloidal proteins in the blood is called the blood colloidal osmotic pressure BCOP. Its effect on capillary exchange accounts for the reabsorption of water. The plasma proteins suspended in blood cannot move across the semipermeable capillary cell membrane, and so they remain in the plasma.

As a result, blood has a higher colloidal concentration and lower water concentration than tissue fluid. It therefore attracts water.

We can also say that the BCOP is higher than the interstitial fluid colloidal osmotic pressure IFCOP , which is always very low because interstitial fluid contains few proteins. Thus, water is drawn from the tissue fluid back into the capillary, carrying dissolved molecules with it. This difference in colloidal osmotic pressure accounts for reabsorption. The normal unit used to express pressures within the cardiovascular system is millimeters of mercury mm Hg.

When blood leaving an arteriole first enters a capillary bed, the CHP is quite high—about 35 mm Hg. Gradually, this initial CHP declines as the blood moves through the capillary so that by the time the blood has reached the venous end, the CHP has dropped to approximately 18 mm Hg. In comparison, the plasma proteins remain suspended in the blood, so the BCOP remains fairly constant at about 25 mm Hg throughout the length of the capillary and considerably below the osmotic pressure in the interstitial fluid.

The net filtration pressure NFP represents the interaction of the hydrostatic and osmotic pressures, driving fluid out of the capillary. Since filtration is, by definition, the movement of fluid out of the capillary, when reabsorption is occurring, the NFP is a negative number. NFP changes at different points in a capillary bed.

Recall that the hydrostatic and osmotic pressures of the interstitial fluid are essentially negligible. Thus, the NFP of 10 mm Hg drives a net movement of fluid out of the capillary at the arterial end.

At this point, there is no net change of volume: Fluid moves out of the capillary at the same rate as it moves into the capillary. Near the venous end of the capillary, the CHP has dwindled to about 18 mm Hg due to loss of fluid. Because the BCOP remains steady at 25 mm Hg, water is drawn into the capillary, that is, reabsorption occurs.

Figure 1.



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